Across TCGA patient cohorts, PRSS48 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS48-associated genes across cancer lineages are Ku80, PCNA, and STAT3_pY705. Each is linked with PRSS48 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS48-to-partner and partner-to-PRSS48 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS48→partner) and Y-score (partner→PRSS48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.271	+3.183	.036	.010	3	1
UCEC	PCNA →	+0.326	+3.169	.006	.019	2	2
UCEC	STAT3_pY705 →	-0.457	-2.999	.001	.035	3	1
UCEC	VHL →	-1.020	-3.000	.006	.036	3	1
UCEC	mTOR_pS2448 →	-0.199	-3.169	.015	.020	2	1
UCEC	p62 Lck ligand →	+0.551	+3.009	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PRSS48 survival (RNA) · tumor vs normal (RNA) · all PRSS48 data types