PRSS46P

Across TCGA patient cohorts, PRSS46P mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS46P-associated genes across cancer lineages are RNU6-376P, TSSK1B, and RNU6-466P. Each is linked with PRSS46P in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS46P-to-partner and partner-to-PRSS46P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-376P grouped by PRSS46P-low versus PRSS46P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS46P→partner) and Y-score (partner→PRSS46P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-376P →	+0.711	+4.868	<.001	.004	3	1
UCEC	TSSK1B →	+0.098	+3.800	<.001	.009	3	1
UCEC	RNU6-466P →	+0.635	+3.661	<.001	.009	3	1
UCEC	NPAP1P2 →	+0.061	+3.871	<.001	.006	3	1
UCEC	UBE2V1P5 →	+0.328	+3.840	<.001	.007	3	1
UCEC	RANP2 →	+0.317	+4.148	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNU6-376P by PRSS46P expression — UCEC

Explore this box plot interactively →