PRSS42P

Across TCGA patient cohorts, PRSS42P mutation is significantly associated with the RNA expression of many other genes, with 1,552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS42P-associated genes across cancer lineages are RNU6-440P, RPL17P12, and OR5D3P. Each is linked with PRSS42P in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS42P-to-partner and partner-to-PRSS42P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-440P grouped by PRSS42P-low versus PRSS42P-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS42P→partner) and Y-score (partner→PRSS42P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-440P →	+0.352	+7.640	<.001	.009	3	2
SKCM	RPL17P12 →	+0.043	+4.328	<.001	.007	3	2
COAD	OR5D3P →	+0.040	+4.332	.007	.006	3	2
COAD	RNU1-52P →	+0.343	+4.824	<.001	.002	3	2
COAD	RN7SL468P →	+0.322	+4.136	<.001	.008	3	2
SKCM	RN7SL277P →	+0.293	+3.937	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,552 associations by consensus.

RNU6-440P by PRSS42P expression — BLCA

Explore this box plot interactively →