PRSS42P

Across TCGA pan-cancer cohorts, PRSS42P RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRSS42P data layer compared with 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRSS42P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRSS42P expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

COAD, HNSC, and KIRP are the cancer types where PRSS42P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.355	0.637	<.001	77	view →
HNSC	DFS	Median	III,IV	0.733	0.588	<.001	57	view →
KIRP	DFS	Tertile	II,III,IV	0.892	0.153	.001	57	view →
BRCA	OS	Median	III,IV	0.896	0.768	.003	25	view →
UCS	DFS	Median	IV	0.909	0.416	.008	24	view →
LAML	DFS	Median	All	0.526	0.258	.006	24	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	23	view →
CESC	DFS	Tertile	All	0.776	0.891	.004	18	view →
UVM	DFS	Tertile	II,III,IV	0.781	0.446	.013	16	view →
LUAD	DFS	Quartile	All	0.198	0.482	.002	15	view →
KIRC	DFS	Tertile	All	0.497	0.704	.009	14	view →
DLBC	DFS	Quartile	IV	0.287	1.000	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRSS42P–COAD (DFS)

Open the COAD breakdown →