PRSS42P

Across TCGA patient cohorts, PRSS42P mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS42P-associated genes across cancer lineages are JNK2, Notch1, and PKC-b-II_pS660. Each is linked with PRSS42P in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS42P-to-partner and partner-to-PRSS42P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PRSS42P-low versus PRSS42P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS42P→partner) and Y-score (partner→PRSS42P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.215	+3.179	.016	.010	3	1
UCEC	Notch1 →	+0.160	+2.000	.011	.032	3	1
UCEC	PKC-b-II_pS660 →	-0.251	-2.000	.044	.032	3	1
UCEC	4E-BP1 →	+0.250	+3.199	.040	.009	3	1
UCEC	PDCD4 →	-0.620	-2.000	.003	.032	2	1
UCEC	Annexin-1 →	+0.580	+2.827	.014	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by PRSS42P expression — UCEC

Explore this box plot interactively →