Across TCGA patient cohorts, PRSS40A mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS40A-associated genes across cancer lineages are EIF2S2P7, TRBV17, and CYP2C19. Each is linked with PRSS40A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS40A-to-partner and partner-to-PRSS40A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS40A→partner) and Y-score (partner→PRSS40A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2S2P7 →	+0.241	+5.262	<.001	.001	3	1
UCEC	TRBV17 →	+0.624	+4.256	<.001	.008	3	1
UCEC	CYP2C19 →	+0.070	+4.211	<.001	.009	3	1
UCEC	OR2M4 →	+0.337	+5.146	<.001	.001	3	1
UCEC	VN2R1P →	+0.170	+4.326	<.001	.007	3	1
UCEC	OR2T1 →	+0.106	+4.937	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

Exploration

PRSS40A survival (RNA) · tumor vs normal (RNA) · all PRSS40A data types