Across TCGA pan-cancer cohorts, PRSS40A RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PRSS40A data layer.
The strongest signal is observed in uveal melanoma (UVM), where higher PRSS40A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS40A expression acts as an unfavorable survival marker, although some lineages such as ESCA and DLBC show a favorable association.
UVM, HNSC, and KICH are the cancer types where PRSS40A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.