Across TCGA pan-cancer cohorts, PRSS3P3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PRSS3P3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRSS3P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS3P3 is over-expressed in tumor.
KIRC are the cancer types where PRSS3P3 tumor–normal differential expression is most reproducible.