PRSS37

Across TCGA pan-cancer cohorts, PRSS37 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRSS37 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRSS37 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS37 expression acts as an unfavorable survival marker.

HNSC, LIHC, and SKCM are the cancer types where PRSS37 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.213	0.686	.011	36	view →
LIHC	OS	Median	All	0.119	0.704	.007	9	view →
SKCM	OS	Median	III,IV	0.129	0.458	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PRSS37–HNSC (OS)

Open the HNSC breakdown →