PRSS35

Across TCGA patient cohorts, PRSS35 mutation is significantly associated with the RNA expression of many other genes, with 2,643 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS35-associated genes across cancer lineages are PABPC1L2A, DAGLB, and C18orf54. Each is linked with PRSS35 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS35-to-partner and partner-to-PRSS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2A grouped by PRSS35-low versus PRSS35-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS35→partner) and Y-score (partner→PRSS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PABPC1L2A →	+0.322	+2.400	<.001	.006	3	3
UCEC	DAGLB →	+0.339	+2.191	<.001	<.001	3	3
UCEC	C18orf54 →	+0.446	+1.807	.008	.004	3	3
UCEC	MIR34AHG →	+0.429	+2.158	<.001	<.001	3	3
SKCM	RN7SL704P →	+0.139	+1.641	.009	.008	3	2
SKCM	MTATP6P9 →	+0.010	+3.369	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,643 associations by consensus.

PABPC1L2A by PRSS35 expression — LUSC

Explore this box plot interactively →