PRSS35

Across TCGA pan-cancer cohorts, PRSS35 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PRSS35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRSS35 RNA is repressed in tumor relative to normal tissue. In most cancer types PRSS35 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and KIRC are the cancer types where PRSS35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−3.550	<.001	11	view →
LUAD	Female	III,IV	−1.792	<.001	11	view →
KIRC	Male	II,III,IV	−1.888	<.001	10	view →
LUSC	Female	II,III,IV	−1.907	<.001	9	view →
BLCA	Male	IV	−1.690	<.001	8	view →
COAD	Male	II,III,IV	+0.458	<.001	7	view →
KIRP	Male	All	−1.974	<.001	6	view →
UCEC	All	All	−1.508	<.001	6	view →
CHOL	All	II,III,IV	+0.570	.001	4	view →
LIHC	All	All	+0.265	.001	4	view →
BRCA	All	All	−0.233	<.001	4	view →
THCA	All	II,III,IV	−0.366	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PRSS35–KICH

Open the KICH breakdown →