PRSS35

Across TCGA cell cohorts, PRSS35 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,659 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRSS35-associated GO terms across cancer lineages are Proteasomal ubiquitin-independent protein catabolic process, Negative regulation of epithelial to mesenchymal transition, and Regulation of myoblast fusion. Each is linked with PRSS35 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRSS35-to-partner and partner-to-PRSS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasomal ubiquitin-independent protein catabolic process grouped by PRSS35-low versus PRSS35-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS35→partner) and Y-score (partner→PRSS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Proteasomal ubiquitin-independent protein catabolic process →	+0.067	+0.923	<.001	.004	3	5
BLOOD_Lymphoma	Negative regulation of epithelial to mesenchymal transition →	-0.078	-0.013	.003	.001	3	5
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.069	+0.010	.009	<.001	3	5
BLOOD_Lymphoma	Phospholipid biosynthetic process →	+0.030	+0.008	.001	.003	3	5
BONE	RNA 3'-end processing →	+0.070	+2.903	<.001	<.001	3	5
SKIN	Post-translational protein targeting to membrane, translocation →	+0.056	+0.858	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,659 associations by consensus.

Proteasomal ubiquitin-independent protein catabolic process by PRSS35 expression — LARGE_INTESTINE

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