PRSS35

Across TCGA cell cohorts, PRSS35 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRSS35-associated genes across cancer lineages are GHRH, ESPNL, and TRIM50. Each is linked with PRSS35 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS35-to-partner and partner-to-PRSS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRH grouped by PRSS35-low versus PRSS35-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS35→partner) and Y-score (partner→PRSS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GHRH →	+0.453	+3.009	<.001	.001	3	1
SKIN	ESPNL →	+0.414	+3.252	<.001	.009	3	1
SKIN	TRIM50 →	+0.050	+3.841	<.001	<.001	3	1
SKIN	SLC49A3 →	+0.917	+3.363	<.001	.004	3	1
SKIN	PRY2 →	+0.495	+2.467	.003	.008	3	1
SKIN	TRIM61 →	+0.532	+3.321	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

GHRH by PRSS35 expression — SKIN

Explore this box plot interactively →