PRSS33

Across TCGA patient cohorts, PRSS33 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS33-associated genes across cancer lineages are Fibroblasts, Macrophages, and CD8+ naive T-cells. Each is linked with PRSS33 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS33-to-partner and partner-to-PRSS33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblasts grouped by PRSS33-low versus PRSS33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS33→partner) and Y-score (partner→PRSS33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibroblasts →	+0.031	+2.071	.015	.040	3	1
UCEC	Macrophages →	+0.019	+2.487	.022	.012	3	1
UCEC	CD8+ naive T-cells →	+0.050	+3.042	.001	.018	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Fibroblasts by PRSS33 expression — UCEC

Explore this box plot interactively →