PRSS3

Across TCGA patient cohorts, PRSS3 mutation is significantly associated with the RNA expression of many other genes, with 170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS3-associated genes across cancer lineages are BMS1P13, UBE2V1P10, and PXMP2. Each is linked with PRSS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS3-to-partner and partner-to-PRSS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMS1P13 grouped by PRSS3-low versus PRSS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS3→partner) and Y-score (partner→PRSS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BMS1P13 →	+0.066	+3.014	<.001	.004	3	2
BLCA	UBE2V1P10 →	+0.169	+7.640	<.001	.009	3	2
SKCM	PXMP2 →	+0.750	+3.331	<.001	.005	3	2
KIRP	RPL7L1P4 →	+0.076	+5.376	.004	.005	3	1
KIRP	EIF4A1P12 →	+0.324	+4.967	<.001	.009	3	1
KIRP	ARHGAP42P4 →	+0.018	+5.264	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 170 associations by consensus.

BMS1P13 by PRSS3 expression — UCEC

Explore this box plot interactively →