PRSS23

Across TCGA patient cohorts, PRSS23 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS23-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and 4E-BP1. Each is linked with PRSS23 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS23-to-partner and partner-to-PRSS23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PRSS23-low versus PRSS23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS23→partner) and Y-score (partner→PRSS23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.481	+2.242	.019	.005	3	3
UCEC	EGFR_pY1068 →	-0.208	-2.087	.016	.005	3	2
UCEC	4E-BP1 →	+0.332	+3.459	<.001	.005	3	2
UCEC	C-Raf →	+0.172	+1.765	<.001	.013	3	2
UCEC	14-3-3_beta →	-0.097	-2.195	.005	.009	3	1
UCEC	EGFR →	-0.170	-3.433	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Caspase-7-cleavedD198 by PRSS23 expression — UCEC

Explore this box plot interactively →