PRSS23

Across TCGA pan-cancer cohorts, PRSS23 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PRSS23’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRSS23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRSS23 is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where PRSS23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRSS23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.164	<.001	12	view →
KIRC	Female	All	+1.221	<.001	11	view →
THCA	Male	All	+2.025	<.001	9	view →
BLCA	Male	All	−1.775	<.001	8	view →
BRCA	All	II,III,IV	+0.769	<.001	6	view →
CHOL	All	All	+2.344	<.001	5	view →
LIHC	All	All	+0.565	.001	5	view →
KIRP	Male	All	−1.337	<.001	4	view →
LUAD	Male	II,III,IV	+0.996	.006	3	view →
UCEC	All	All	−1.184	.003	2	view →
PRAD	All	All	−0.534	<.001	2	view →
ESCA	Male	All	+1.346	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PRSS23–HNSC

Open the HNSC breakdown →