PRSS23

Across TCGA cell cohorts, PRSS23 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible PRSS23-associated genes across cancer lineages are OR4N4, TP53TG3E, and OR13C2. Each is linked with PRSS23 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS23-to-partner and partner-to-PRSS23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by PRSS23-low versus PRSS23-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS23→partner) and Y-score (partner→PRSS23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR4N4 →	+0.021	+5.000	.004	.006	3	1
PANCREAS	TP53TG3E →	+0.012	+5.000	<.001	.006	3	1
PANCREAS	OR13C2 →	+0.012	+5.000	<.001	.006	3	1
PANCREAS	OR8K3 →	+0.023	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUAD	SULT6B1 →	+1.174	+4.662	<.001	.005	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR4N4 by PRSS23 expression — PANCREAS

Explore this box plot interactively →