PRSS22

Across TCGA patient cohorts, PRSS22 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS22-associated genes across cancer lineages are RN7SL750P, HHLA3-AS1, and LINC02536. Each is linked with PRSS22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS22-to-partner and partner-to-PRSS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL750P grouped by PRSS22-low versus PRSS22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS22→partner) and Y-score (partner→PRSS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL750P →	+0.249	+3.113	.001	.001	3	2
UCEC	HHLA3-AS1 →	+0.298	+3.530	.004	.007	3	2
HNSC	LINC02536 →	+0.066	+5.368	.003	.005	3	1
UCEC	IL21 →	+0.233	+3.834	<.001	<.001	3	1
UCEC	MIR4539 →	+1.204	+3.273	<.001	.001	3	1
STAD	MIR6803 →	+0.609	+5.798	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RN7SL750P by PRSS22 expression — UCEC

Explore this box plot interactively →