PRSS16

Across TCGA patient cohorts, PRSS16 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS16-associated genes across cancer lineages are Smad1, 14-3-3_beta, and eIF4E. Each is linked with PRSS16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS16-to-partner and partner-to-PRSS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by PRSS16-low versus PRSS16-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS16→partner) and Y-score (partner→PRSS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Smad1 →	+0.137	+2.816	.044	.036	2	2
UCEC	14-3-3_beta →	-0.083	-2.973	.036	.035	3	1
UCEC	eIF4E →	+0.226	+3.700	.006	.001	3	1
UCEC	Fibronectin →	-0.270	-1.990	.037	.030	3	1
UCEC	JNK2 →	+0.195	+2.348	.012	.018	3	1
UCEC	MEK1 →	+0.439	+2.807	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Smad1 by PRSS16 expression — LUSC

Explore this box plot interactively →