PRSS16

Across TCGA cell cohorts, PRSS16 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRSS16-associated genes across cancer lineages are MC3R, AICDA, and EQTN. Each is linked with PRSS16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS16-to-partner and partner-to-PRSS16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC3R grouped by PRSS16-low versus PRSS16-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS16→partner) and Y-score (partner→PRSS16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MC3R →	+0.228	+3.884	<.001	.005	3	1
LUNG_SCLC	AICDA →	+0.075	+3.220	<.001	.002	3	1
LUNG_SCLC	EQTN →	+0.100	+2.984	.004	.005	3	1
LUNG_SCLC	CYLC2 →	+0.007	+3.169	.004	.005	3	1
LUNG_SCLC	USP17L13 →	+0.007	+3.614	<.001	.001	3	1
LUNG_SCLC	USP17L17 →	+0.007	+3.614	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MC3R by PRSS16 expression — SKIN

Explore this box plot interactively →