PRSS1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PRSS1 mutation is significantly associated with the RNA expression of many other genes, with 2,901 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS1-associated genes across cancer lineages are RNFT2, MIR1293, and ALKBH1. Each is linked with PRSS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS1-to-partner and partner-to-PRSS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS1→partner) and Y-score (partner→PRSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRNFT2 →+0.613+2.234.008.00633
LUSCMIR1293 →+0.466+3.286.004.00832
UCECALKBH1 →+0.484+3.749<.001<.00132
UCECPSMC1 →+0.512+2.708.008.00332
UCECTRPC4AP →+0.450+3.087<.001<.00132
UCECACTR5 →+0.394+2.415.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,901 associations by consensus.

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