Across TCGA pan-cancer cohorts, PRSS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PRSS1 data layer compared with 6 for mutation status and 1 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PRSS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS1 expression acts as an unfavorable survival marker, although some lineages such as READ and ACC show a favorable association.
UCEC, STAD, and READ are the cancer types where PRSS1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.