Across TCGA patient cohorts, PRSS1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRSS1-associated genes across cancer lineages are 4E-BP1_pT37_T46, Notch1, and p38-MAPK_pT180_Y182. Each is linked with PRSS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRSS1-to-partner and partner-to-PRSS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS1→partner) and Y-score (partner→PRSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pT37_T46 →	-0.376	-2.321	.012	.032	3	3
UCEC	Notch1 →	+0.214	+2.115	<.001	.019	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.474	-2.459	.015	.019	3	2
UCEC	Annexin-1 →	+0.625	+2.189	.006	.034	3	2
SKCM	cIAP →	+0.109	+1.900	.048	.028	3	2
UCEC	eIF4E →	+0.222	+3.169	.016	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Exploration

PRSS1 survival (RNA) · tumor vs normal (RNA) · all PRSS1 data types