Across TCGA cell cohorts, PRSS1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PRSS1-associated genes across cancer lineages are C1QC, GSTA3, and HSD3B2. Each is linked with PRSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRSS1-to-partner and partner-to-PRSS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRSS1→partner) and Y-score (partner→PRSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C1QC →	+0.026	+3.584	<.001	.003	3	1
LUNG_SCLC	GSTA3 →	+0.056	+3.938	<.001	<.001	3	1
LUNG_SCLC	HSD3B2 →	+0.059	+3.070	<.001	.009	3	1
LUNG_SCLC	SMIM9 →	+0.037	+3.232	.003	.008	3	1
SKIN	UMOD →	+0.086	+4.242	<.001	.001	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.047	+2.672	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

PRSS1 survival (RNA) · tumor vs normal (RNA) · all PRSS1 data types