PRRX2-AS1

Across TCGA pan-cancer cohorts, PRRX2-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PRRX2-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRRX2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRRX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.

COAD, UVM, and KICH are the cancer types where PRRX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.213	0.540	<.001	81	view →
UVM	DFS	Tertile	All	0.360	0.780	<.001	63	view →
KICH	DFS	Tertile	All	0.043	0.971	<.001	63	view →
ESCA	DFS	Median	III,IV	0.547	0.305	.003	49	view →
HNSC	OS	Tertile	IV	0.836	0.664	.007	36	view →
LGG	DFS	Tertile	All	0.547	0.755	<.001	36	view →
UCEC	DFS	Tertile	All	0.723	0.860	<.001	36	view →
THCA	OS	Tertile	IV	0.626	1.000	.002	33	view →
MESO	DFS	Median	III,IV	0.271	0.430	.015	25	view →
KIRP	DFS	Tertile	All	0.680	0.925	.006	18	view →
SKCM	OS	Tertile	III,IV	0.538	0.333	.009	15	view →
PRAD	OS	Tertile	All	0.817	0.890	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PRRX2-AS1–COAD (DFS)

Open the COAD breakdown →