PRRX2-AS1

Across TCGA pan-cancer cohorts, PRRX2-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRRX2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PRRX2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRRX2-AS1 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

LUSC, ESCA, and LUAD are the cancer types where PRRX2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRRX2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	III,IV	+0.220	.002	5	view →
ESCA	All	II,III,IV	+0.755	.011	2	view →
LUAD	Female	All	+0.132	.003	2	view →
UCEC	All	All	−0.086	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRRX2-AS1–LUSC

Open the LUSC breakdown →