PRRT3

Across TCGA cell cohorts, PRRT3 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRRT3-associated genes across cancer lineages are XAGE5, OR6J1, and KHDRBS2. Each is linked with PRRT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRRT3-to-partner and partner-to-PRRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by PRRT3-low versus PRRT3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRRT3→partner) and Y-score (partner→PRRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	XAGE5 →	+0.713	+5.643	<.001	.002	3	2
BLOOD_Leukemia	OR6J1 →	+0.038	+3.234	<.001	.008	3	2
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1
OESOPHAGUS	ACTRT1 →	+0.023	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC8 →	+0.020	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	CSTL1 →	+0.549	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

XAGE5 by PRRT3 expression — BLOOD_Lymphoma

Explore this box plot interactively →