PRR35

Across TCGA patient cohorts, PRR35 mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR35-associated genes across cancer lineages are RNU6-1318P, RNU6ATAC7P, and LSP1P3. Each is linked with PRR35 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR35-to-partner and partner-to-PRR35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by PRR35-low versus PRR35-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR35→partner) and Y-score (partner→PRR35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1318P →	+0.275	+3.555	<.001	.004	3	2
SKCM	RNU6ATAC7P →	+0.182	+3.186	<.001	.009	3	2
UCEC	LSP1P3 →	+0.414	+3.063	<.001	.008	3	2
UCEC	RPL7P46 →	+0.356	+3.727	.005	.006	3	2
UCEC	PCYT1B-AS1 →	+0.319	+3.734	.001	.001	3	2
UCEC	RN7SL248P →	+0.202	+5.307	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

RNU6-1318P by PRR35 expression — SKCM

Explore this box plot interactively →