PRR23C

Across TCGA patient cohorts, PRR23C mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR23C-associated genes across cancer lineages are ERK2, Ku80, and MEK1. Each is linked with PRR23C in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR23C-to-partner and partner-to-PRR23C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PRR23C-low versus PRR23C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR23C→partner) and Y-score (partner→PRR23C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.213	+3.584	.004	.002	3	1
UCEC	Ku80 →	+0.207	+1.710	.022	.025	3	1
UCEC	MEK1 →	+0.443	+3.807	.001	<.001	3	1
UCEC	MSH2 →	-0.322	-2.433	<.001	.018	3	1
UCEC	MSH6 →	-0.408	-2.459	.001	.018	3	1
UCEC	PDCD4 →	-0.485	-1.874	.007	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by PRR23C expression — UCEC

Explore this box plot interactively →