PRR23C

Across TCGA pan-cancer cohorts, PRR23C RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PRR23C data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PRR23C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRR23C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

CESC, LIHC, and KIRC are the cancer types where PRR23C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	III,IV	0.385	0.779	.004	60	view →
LIHC	DFS	Tertile	All	0.283	0.565	.001	60	view →
KIRC	DFS	Tertile	III,IV	0.178	0.512	.001	48	view →
MESO	DFS	Tertile	III,IV	0.138	0.440	<.001	45	view →
LUSC	OS	Tertile	II,III,IV	0.434	0.798	.009	36	view →
COAD	OS	Tertile	All	0.754	0.881	.042	21	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
KIRP	OS	Tertile	All	0.885	0.960	.029	15	view →
ACC	OS	Tertile	II,III,IV	0.196	0.592	.048	15	view →
THCA	DFS	Tertile	IV	0.514	0.937	<.001	15	view →
OV	OS	Tertile	II,III,IV	0.651	0.701	.030	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PRR23C–CESC (OS)

Open the CESC breakdown →