PRR18

Across TCGA cell cohorts, PRR18 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,175 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRR18-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and RNA splicing, via transesterification reactions. Each is linked with PRR18 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRR18-to-partner and partner-to-PRR18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PRR18-low versus PRR18-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR18→partner) and Y-score (partner→PRR18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of myoblast fusion →	+0.128	+0.312	<.001	.009	3	7
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.129	+0.318	<.001	.007	3	7
SOFT_TISSUE	RNA splicing, via transesterification reactions →	+0.057	+0.186	.001	.003	3	6
SOFT_TISSUE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.058	+0.183	.001	.004	3	6
SOFT_TISSUE	mRNA splicing, via spliceosome →	+0.058	+0.183	.001	.004	3	6
LUNG_SCLC	Regulation of myoblast fusion →	+0.122	+1.640	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,175 associations by consensus.

Negative regulation of myoblast fusion by PRR18 expression — STOMACH

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