PRR18

Across TCGA pan-cancer cohorts, PRR18 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PRR18’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRR18 RNA is repressed in tumor relative to normal tissue. In most cancer types PRR18 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where PRR18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRR18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.515	<.001	10	view →
KICH	All	All	−0.432	<.001	9	view →
KIRC	Male	II,III,IV	−0.309	<.001	9	view →
LIHC	Female	All	−1.049	<.001	6	view →
BRCA	All	III,IV	−0.256	<.001	6	view →
CHOL	Male	All	−1.714	<.001	4	view →
READ	Female	All	−0.126	.013	2	view →
LUSC	All	III,IV	−0.598	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PRR18–THCA

Open the THCA breakdown →