PRR15L

Across TCGA pan-cancer cohorts, PRR15L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PRR15L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRR15L RNA is repressed in tumor relative to normal tissue. In most cancer types PRR15L is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where PRR15L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRR15L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−3.996	<.001	12	view →
THCA	Male	All	−2.271	<.001	11	view →
HNSC	All	II,III,IV	−1.625	<.001	9	view →
LUSC	Female	II,III,IV	−3.272	<.001	8	view →
KICH	Male	All	−2.515	<.001	8	view →
BRCA	All	III,IV	+2.365	<.001	6	view →
CHOL	Male	All	+4.955	<.001	5	view →
BLCA	All	IV	+2.658	.034	5	view →
STAD	All	All	+2.118	<.001	5	view →
UCEC	All	All	+2.542	<.001	4	view →
KIRP	All	III,IV	−1.661	.012	4	view →
LIHC	Female	All	+1.349	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PRR15L–KIRC

Open the KIRC breakdown →