PRR14

Across TCGA patient cohorts, PRR14 mutation is significantly associated with the RNA expression of many other genes, with 1,226 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR14-associated genes across cancer lineages are GOLGA2P3Y, ZFP3, and MACC1. Each is linked with PRR14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR14-to-partner and partner-to-PRR14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA2P3Y grouped by PRR14-low versus PRR14-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR14→partner) and Y-score (partner→PRR14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GOLGA2P3Y →	+0.021	+5.455	<.001	.001	3	2
UCEC	ZFP3 →	-0.678	-1.925	.002	.005	3	2
UCEC	MACC1 →	-0.789	-3.563	.001	.002	3	2
UCEC	NDUFA6 →	+0.486	+2.332	<.001	<.001	3	2
UCEC	KAZN →	-0.707	-1.915	.002	.005	3	2
UCEC	SHPK →	+0.418	+2.332	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,226 associations by consensus.

GOLGA2P3Y by PRR14 expression — BLCA

Explore this box plot interactively →