PRR11

Across TCGA patient cohorts, PRR11 mutation is significantly associated with the RNA expression of many other genes, with 561 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR11-associated genes across cancer lineages are CDRT8, DOLPP1, and GLOD4. Each is linked with PRR11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR11-to-partner and partner-to-PRR11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDRT8 grouped by PRR11-low versus PRR11-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR11→partner) and Y-score (partner→PRR11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CDRT8 →	+0.128	+3.006	.007	.006	3	2
UCEC	DOLPP1 →	+0.626	+3.595	.002	.001	3	2
UCEC	GLOD4 →	+0.506	+3.595	.008	.001	3	2
UCEC	RNU6-1085P →	+0.331	+2.921	<.001	.001	3	2
UCEC	RN7SL98P →	+0.118	+2.675	.003	.007	3	2
UCEC	YWHAE →	+0.406	+3.617	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 561 associations by consensus.

CDRT8 by PRR11 expression — LUSC

Explore this box plot interactively →