PRR11

Across TCGA patient cohorts, PRR11 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRR11-associated genes across cancer lineages are PEA-15_pS116, ERK2, and FOXO3a_pS318_S321. Each is linked with PRR11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRR11-to-partner and partner-to-PRR11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by PRR11-low versus PRR11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRR11→partner) and Y-score (partner→PRR11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.355	+2.321	.044	.035	3	2
UCEC	ERK2 →	+0.244	+2.321	.011	.035	2	2
UCEC	FOXO3a_pS318_S321 →	-0.135	-2.321	.031	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.308	.019	.036	3	1
UCEC	MEK1 →	+0.445	+3.169	.015	.019	3	1
UCEC	Notch1 →	+0.162	+2.321	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PEA-15_pS116 by PRR11 expression — UCEC

Explore this box plot interactively →