PRPSAP2

Across TCGA patient cohorts, PRPSAP2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPSAP2-associated genes across cancer lineages are Annexin_VII, EGFR_pY1068, and ERK2. Each is linked with PRPSAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPSAP2-to-partner and partner-to-PRPSAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by PRPSAP2-low versus PRPSAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPSAP2→partner) and Y-score (partner→PRPSAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.157	-2.312	.009	.034	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.321	.020	.034	3	1
UCEC	ERK2 →	+0.189	+2.999	.024	.035	3	1
UCEC	FoxM1 →	+0.373	+3.469	<.001	.002	3	1
UCEC	ACVRL1 →	-0.186	-3.156	.001	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.148	-2.102	.044	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin_VII by PRPSAP2 expression — UCEC

Explore this box plot interactively →