PRPSAP1

Across TCGA patient cohorts, PRPSAP1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPSAP1-associated genes across cancer lineages are MEK1, PDK1_pS241, and STAT3_pY705. Each is linked with PRPSAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPSAP1-to-partner and partner-to-PRPSAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PRPSAP1-low versus PRPSAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPSAP1→partner) and Y-score (partner→PRPSAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.489	+2.459	.005	.020	3	1
UCEC	PDK1_pS241 →	+0.198	+2.472	.016	.011	3	1
UCEC	STAT3_pY705 →	-0.289	-2.459	.022	.020	3	1
UCEC	YB-1_pS102 →	-0.193	-3.000	.031	.036	3	1
UCEC	Caspase-7-cleavedD198 →	+0.743	+2.459	.009	.020	3	1
UCEC	Cyclin-B1 →	+0.534	+2.459	.049	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by PRPSAP1 expression — UCEC

Explore this box plot interactively →