PRPS2

Across TCGA patient cohorts, PRPS2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,667 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRPS2-associated genes across cancer lineages are POLA1, RBBP7, and FANCB. Each is linked with PRPS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRPS2-to-partner and partner-to-PRPS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRPS2 versus POLA1 in LSCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPS2→partner) and Y-score (partner→PRPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLA1 →	+0.709	+0.351	<.001	.001	3	7
OV	RBBP7 →	+0.774	+0.491	<.001	<.001	3	5
LSCC	FANCB →	+0.713	+0.266	<.001	.001	3	5
GBM	PTPN5 →	-1.213	-0.391	.002	.001	3	4
BRCA	CLEC1A →	-0.530	-0.260	<.001	.005	3	4
LSCC	THY1 →	-0.712	-0.422	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,667 associations by consensus.

PRPS2 vs POLA1 — LSCC

Explore this scatter interactively →