PRPH

Across TCGA cell cohorts, PRPH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,966 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRPH-associated GO terms across cancer lineages are Regulation of proteasomal protein catabolic process, Regulation of proteasomal ubiquitin-dependent protein catabolic process, and Cytoplasmic translation. Each is linked with PRPH in more than 10 cancer types. Because this analysis shows association rather than direction, both PRPH-to-partner and partner-to-PRPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of proteasomal protein catabolic process grouped by PRPH-low versus PRPH-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPH→partner) and Y-score (partner→PRPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of proteasomal protein catabolic process →	+0.059	+0.489	.003	.003	2	11
BLOOD_Lymphoma	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.053	+0.734	<.001	.004	3	10
OESOPHAGUS	Cytoplasmic translation →	+0.103	+1.259	.001	<.001	3	10
OESOPHAGUS	Aerobic electron transport chain →	+0.112	+1.130	.004	<.001	3	9
OESOPHAGUS	Purine nucleoside triphosphate biosynthetic process →	+0.087	+1.272	.005	<.001	3	9
OESOPHAGUS	Purine ribonucleoside triphosphate biosynthetic process →	+0.087	+1.272	.005	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,966 associations by consensus.

Regulation of proteasomal protein catabolic process by PRPH expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →