PRPH

Across TCGA cell cohorts, PRPH mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPH-associated genes across cancer lineages are CFHR2, IZUMO2, and KRTAP17-1. Each is linked with PRPH in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPH-to-partner and partner-to-PRPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by PRPH-low versus PRPH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPH→partner) and Y-score (partner→PRPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	2
OESOPHAGUS	IZUMO2 →	+0.043	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP17-1 →	+0.023	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
BLOOD_Leukemia	MMP20 →	+0.041	+3.705	.003	.007	3	1
BLOOD_Leukemia	TRIM49B →	+0.111	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CFHR2 by PRPH expression — LARGE_INTESTINE

Explore this box plot interactively →