PRPH

Across TCGA cell cohorts, PRPH mutation is significantly associated with the mutation status of many other genes, with 2,461 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPH-associated genes across cancer lineages are DNAJC13, LMBRD1, and SH3BP1. Each is linked with PRPH in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPH-to-partner and partner-to-PRPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC13 grouped by PRPH-low versus PRPH-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPH→partner) and Y-score (partner→PRPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DNAJC13 →	+6.044	+6.044	.001	.001	1	3
CNS	LMBRD1 →	+5.044	+5.614	.003	.003	1	3
SKIN	SH3BP1 →	+4.824	+5.392	.004	.004	1	3
CNS	ZNF516 →	+4.459	+5.277	.005	.005	1	3
CNS	NOTCH2 →	+6.044	+6.044	.001	.001	1	3
CNS	PTPRH →	+4.459	+5.277	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,461 associations by consensus.

DNAJC13 by PRPH expression — CNS

Explore this box plot interactively →