PRPF8

Across TCGA cell cohorts, PRPF8 mutation is significantly associated with the RNA expression of many other genes, with 1,016 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRPF8-associated genes across cancer lineages are ANKRD54, FAM149A, and BCL7A. Each is linked with PRPF8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF8-to-partner and partner-to-PRPF8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD54 grouped by PRPF8-low versus PRPF8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF8→partner) and Y-score (partner→PRPF8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ANKRD54 →	+0.520	+2.451	.001	.009	3	2
LARGE_INTESTINE	FAM149A →	+1.616	+3.502	<.001	.001	3	2
LARGE_INTESTINE	BCL7A →	+0.855	+3.588	.001	<.001	3	2
BLOOD_Leukemia	RIC8B →	+0.619	+2.837	.003	<.001	3	2
LARGE_INTESTINE	TBCCD1 →	+0.561	+3.169	.003	.009	3	2
LARGE_INTESTINE	GOT1 →	+0.631	+3.169	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,016 associations by consensus.

ANKRD54 by PRPF8 expression — LARGE_INTESTINE

Explore this box plot interactively →