PRPF6

Across TCGA patient cohorts, PRPF6 mutation is significantly associated with the RNA expression of many other genes, with 2,609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF6-associated genes across cancer lineages are SLC19A3, FAXDC2, and RANP5. Each is linked with PRPF6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF6-to-partner and partner-to-PRPF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC19A3 grouped by PRPF6-low versus PRPF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF6→partner) and Y-score (partner→PRPF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC19A3 →	-0.522	-3.989	.005	<.001	3	3
UCEC	FAXDC2 →	-0.592	-2.247	<.001	.001	3	3
BLCA	RANP5 →	+0.049	+2.623	.004	.006	3	3
CESC	MIR194-1 →	+0.541	+4.069	<.001	.005	3	2
BLCA	PHBP15 →	+0.028	+4.066	<.001	.001	3	2
BLCA	RN7SL426P →	+0.319	+3.129	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,609 associations by consensus.

SLC19A3 by PRPF6 expression — UCEC

Explore this box plot interactively →