PRPF40B

Across TCGA pan-cancer cohorts, PRPF40B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PRPF40B’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PRPF40B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PRPF40B is over-expressed in tumor, although a few such as CCRCC and LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where PRPF40B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRPF40B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	−0.363	<.001	9	view →
LUAD	All	II,III,IV	−0.190	<.001	7	view →
LSCC	Male	II,III,IV	+0.136	.003	4	view →
PDAC	All	II,III,IV	−0.252	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PRPF40B–CCRCC

Open the CCRCC breakdown →