PRPF40B

Across TCGA pan-cancer cohorts, PRPF40B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PRPF40B data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PRPF40B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRPF40B expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

CESC, KIRC, and LIHC are the cancer types where PRPF40B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.433	0.640	.001	74	view →
KIRC	DFS	Tertile	IV	0.341	0.665	<.001	55	view →
LIHC	DFS	Tertile	All	0.417	0.606	<.001	51	view →
COAD	DFS	Tertile	All	0.730	0.839	.004	34	view →
READ	DFS	Median	All	0.271	0.768	.006	25	view →
UCS	DFS	Tertile	IV	0.936	0.364	.024	24	view →
LUSC	DFS	Median	III,IV	0.230	0.496	.006	21	view →
ESCA	OS	Quartile	All	1.000	0.323	.006	21	view →
SCLC	OS	Quartile	All	0.770	0.492	.014	14	view →
PRAD	DFS	Median	All	0.745	0.805	.022	12	view →
LGG	OS	Quartile	All	0.741	0.945	.001	10	view →
ACC	DFS	Median	All	0.199	0.586	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PRPF40B–CESC (DFS)

Open the CESC breakdown →