PRPF40B

Across TCGA patient cohorts, PRPF40B mutation is significantly associated with the RNA expression of many other genes, with 1,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF40B-associated genes across cancer lineages are HSPD1P15, MIR378E, and RNU4-79P. Each is linked with PRPF40B in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF40B-to-partner and partner-to-PRPF40B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPD1P15 grouped by PRPF40B-low versus PRPF40B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40B→partner) and Y-score (partner→PRPF40B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HSPD1P15 →	+0.166	+3.201	<.001	.009	3	3
UCEC	MIR378E →	+0.201	+2.930	<.001	.001	3	3
LUAD	RNU4-79P →	+0.198	+4.155	<.001	.007	3	3
COAD	FUT11 →	+0.508	+3.230	.003	.009	3	3
UCEC	FN3KRP →	+0.339	+2.584	.007	.001	3	3
COAD	LEO1 →	+0.501	+3.196	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,739 associations by consensus.

HSPD1P15 by PRPF40B expression — LUAD

Explore this box plot interactively →