PRPF40B

Across TCGA patient cohorts, PRPF40B mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRPF40B-associated genes across cancer lineages are ATM, Annexin-1, and Caspase-7-cleavedD198. Each is linked with PRPF40B in more than 2 cancer types. Because this analysis shows association rather than direction, both PRPF40B-to-partner and partner-to-PRPF40B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PRPF40B-low versus PRPF40B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40B→partner) and Y-score (partner→PRPF40B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.602	-2.087	<.001	.005	3	3
UCEC	Annexin-1 →	+0.513	+2.479	.011	.010	3	2
COAD	Caspase-7-cleavedD198 →	+1.413	+2.824	<.001	.034	3	2
UCEC	Caspase-8 →	-0.229	-3.558	.017	.002	3	2
COAD	eEF2K →	-0.345	-3.161	.043	.019	3	2
UCEC	eIF4E →	+0.201	+2.584	.012	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by PRPF40B expression — UCEC

Explore this box plot interactively →