PRPF40B

Across TCGA cell cohorts, PRPF40B mutation is significantly associated with the RNA expression of many other genes, with 749 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRPF40B-associated genes across cancer lineages are VCY, KRTAP9-2, and GALP. Each is linked with PRPF40B in more than 1 cancer types. Because this analysis shows association rather than direction, both PRPF40B-to-partner and partner-to-PRPF40B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY grouped by PRPF40B-low versus PRPF40B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRPF40B→partner) and Y-score (partner→PRPF40B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VCY →	+0.289	+4.228	<.001	.006	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
BLOOD_Leukemia	GALP →	+0.031	+5.201	.001	.006	3	1
BLOOD_Leukemia	IFNA4 →	+0.058	+4.922	<.001	.009	3	1
LARGE_INTESTINE	EIF3L →	+0.506	+3.257	.002	.002	3	1
LARGE_INTESTINE	DEPDC5 →	+0.676	+3.321	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 749 associations by consensus.

VCY by PRPF40B expression — OVARY

Explore this box plot interactively →